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| Lexapro 5 mg |
Brand Name: Lexapro
Generic Name: Nexito, Citadep, Celexa
Manufacturer: Forest Pharmaceuticals
Diseases: Depression, Anxiety
Dosage: 5mg / 10mg / 20mg
In August 2002, the FDA approved Lexapro for the treatment of major depressive disorder. Lexapro's efficacy and tolerability have been proven in clinical trials. The recommended dose of Lexapro is 10 mg daily.
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| Lexapro 10 mg |
Each year, nearly 19 million adult Americans suffer from depression. According to the predictios of the World Health Organization depression will become the leading cause of disability by the year 2020.
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| Lexapro 20 mg |
What is Lexapro (Escitalopram)?
Escitalopram is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs). Escitalopram affects chemicals in the brain that may become unbalanced and cause depression or anxiety.
Escitalopram is used to treat anxiety in adults and major depressive disorder in adults and adolescents who are at least 12 years old.
Escitalopram may also be used for other purposes not listed in this medication guide.
Important information about Lexapro
Do not take Lexapro together with a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate). You must wait at least 14 days after stopping an MAOI before you can take Lexapro. After you stop taking Lexapro, you must wait at least 14 days before you start taking an MAOI.
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment with Lexapro.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Lexapro, do not stop taking the medication without first talking to your doctor.
It is dangerous to try and purchase Lexapro on the Internet or from vendors outside of the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Samples of Lexapro purchased on the Internet have been found to contain haloperidol (Haldol), a potent antipsychotic drug with dangerous side effects. For more information, contact the U.S. Food and Drug Administration (FDA) or visit www.fda.gov/buyonlineguide
Before taking Lexapro
Do not use Lexapro if you are using an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam). Serious and sometimes fatal reactions can occur when these medicines are taken with Lexapro. You must wait at least 14 days after stopping an MAO inhibitor before you can take escitalopram. After you stop taking Lexapro, you must wait at least 14 days before you start taking an MAOI.
Before taking this medicine, tell your doctor if you are allergic to any drugs, or if you have:
- liver or kidney disease;
- seizures or epilepsy;
- bipolar disorder (manic depression); or
- a history of drug abuse or suicidal thoughts.
You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.
Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment with Lexapro.
FDA pregnancy category C. SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you are planning a pregnancy, or if you become pregnant while taking Lexapro, do not stop taking the medication without first talking to your doctor. Escitalopram can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give Lexapro to anyone younger than 12 years old without the advice of a doctor.
How should I take Lexapro?
Take Lexapro exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Your doctor may occasionally change your dose to make sure you get the best results from the medication.
Take each dose of Lexapro with a full glass of water.
Try to take the medicine at the same time each day. Follow the directions on your prescription label.
To be sure you get the correct dose of liquid Lexapro, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
It may take 4 weeks or longer before you start feeling better. Do not stop using Lexapro without first talking to your doctor. You may have unpleasant side effects if you stop taking this medication suddenly. Store Lexapro at room temperature away from moisture and heat.
DOSING
The usual starting dose of escitalopram is 10 mg once daily in the morning or evening. The dose may be increased to 20 mg once daily after 1 week. Benefit may not be seen until treatment has been given for up to 4 weeks. A daily dose of 20 mg may not be anymore effective than 10 mg daily for treatment of depression. Escitalopram can be taken with or without food.
What happens if I miss a dose?
Take the missed dose as soon as you remember. However, if it is almost time for the next regularly scheduled dose, skip the missed dose and take the next one as directed. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention if you think you have taken too much of this medication. Overdose symptoms may include nausea, vomiting, tremor, sweating, rapid heartbeat, confusion, dizziness, seizures, and coma.
What should I avoid while taking Lexapro?
Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin and NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with escitalopram may cause you to bruise or bleed easily.
Avoid drinking alcohol, which can increase some of the side effects of Lexapro. Lexapro can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
Tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures or anxiety). They can add to sleepiness caused by Lexapro.
What are the possible side effects of escitalopram (Lexapro)?
Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
Call your doctor at once if you have any of these serious side effects:
- very stiff (rigid) muscles, high fever, sweating, fast or uneven heartbeats, tremors, overactive reflexes;
- nausea, vomiting, diarrhea, loss of appetite, feeling unsteady, loss of coordination; or
- headache, trouble concentrating, memory problems, weakness, confusion, hallucinations, fainting, seizure, shallow breathing or breathing that stops.
- drowsiness, dizziness;
- sleep problems (insomnia);
- mild nausea, gas, heartburn, upset stomach, constipation;
- weight changes;
- decreased sex drive, impotence, or difficulty having an orgasm; or
- dry mouth, yawning, ringing in your ears.
What other drugs will affect Lexapro?
Talk to your doctor before taking any medicine for pain, arthritis, fever, or swelling. This includes aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), diclofenac (Voltaren), indomethacin, piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others. Taking any of these drugs with Lexapro may cause you to bruise or bleed easily.
Before taking Lexapro, tell your doctor if you are using any of the following medicines:
- carbamazepine (Carbatrol, Tegretol);
- cimetidine (Tagamet);
- lithium (Lithobid, Eskalith);
- a blood thinner such as warfarin (Coumadin);
- any other antidepressants such as amitriptyline (Elavil), citalopram (Celexa), fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Paxil), or sertraline (Zoloft); or
- almotriptan (Axert), frovatriptan (Frova), sumatriptan (Imitrex), naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan (Zomig).
There may be other drugs not listed that can affect Lexapro. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.
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Clinical Results
Lexapro's approval was based on a double-bind, placebo-controlled, multi-center study that involved 491 subjects with ongoing major depressive episodes. The subjects were randomized for eight weeks to one of four trial arms: placebo, Lexapro at 10 mg per day, Lexapro at 20 mg per day, or Celexa at 40 mg per day.
The results showed that Lexapro at 10 mg per day and 20 mg per day demonstrated significantly greater improvement relative to placebo. Additionally, Lexapro 10 mg was shown to be as effective as 40 mg of Celexa on the major efficacy outcome variables. Summarily, Lexapro was statistically superior to placebo in all common efficacy measures, beginning at week one and continuing throughout the study period. All treatment groups had a low rate of discontinuation due to adverse events.
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